MovDisordV3, Main, Exploration, bibRecord, 001B00

Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15

Identifieur interne : 001B00 ( Main/Exploration ); précédent : 001A99; suivant : 001B01

Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15

Auteurs : Anne Weissbach [Allemagne] ; Ana Djarmati [Allemagne] ; Christine Klein [Allemagne] ; Nataša Dragaševi [Serbie] ; Christine Zühlke [Allemagne] ; Aleksandar Rakovi [Allemagne] ; Miodrag Gužvi [Allemagne, Serbie] ; Elisabeth Butz [Allemagne] ; Holger Tönnies [Allemagne] ; Reiner Siebert [Allemagne] ; Igor Petrovi [Serbie] ; Marina Svetel [Serbie] ; Vladimir S. Kosti [Serbie] ; Katja Lohmann [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2010-08-15.

RBID : ISTEX:D404B81912783DCC19C384A379AA72D35521AA24

Descripteurs français

Pascal (Inist)
- Ataxie spinocérébelleuse, Chromosome 15, Hétérogénéité, Pathologie du système nerveux.
Wicri :
- geographic : Serbie.

English descriptors

KwdEn :
- Adult, Aged, Chromosome 15, Chromosomes, Human, Pair 15 (genetics), DNA-Binding Proteins (genetics), Family Health, Female, Genetic Heterogeneity, Genome-Wide Association Study (methods), Heterogeneity, Humans, Lod Score, Male, Middle Aged, Nervous system diseases, SCA11, Serbia (epidemiology), Serbia (ethnology), Spinocerebellar Ataxias (genetics), Spinocerebellar ataxia, Trinucleotide Repeats (genetics), chromosome 15, genetic heterogeneity, genome‐wide linkage analysis, spinocerebellar ataxia.
MESH :
- chemical , genetics : DNA-Binding Proteins.
- geographic , epidemiology : Serbia.
- geographic , ethnology : Serbia.
- genetics : Chromosomes, Human, Pair 15, Spinocerebellar Ataxias, Trinucleotide Repeats.
- methods : Genome-Wide Association Study.
- Adult, Aged, Family Health, Female, Genetic Heterogeneity, Humans, Lod Score, Male, Middle Aged.

Abstract

Autosomal dominant spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous group of neurodegenerative disorders. We investigated an SCA family from Serbia of Roma ethnic origin; four affected and nine unaffected family members underwent a detailed neurological examination. The presenting symptom in all patients was gait unsteadiness in early adulthood. Additional features included pyramidal signs, depression, and cognitive impairment. The condition follows an autosomal dominant pattern of inheritance. After excluding repeat expansions in nine known SCA genes, a genome‐wide linkage analysis with 412 microsatellite markers localized the putative disease gene to a 40.7 cM (42.5 Mb) region on chromosome 15q between markers D15S1006 and D15S116. The maximum model‐based multipoint LOD score was 1.75. This region is only 4.3 Mb away from the SCA11 (TTBK2) gene. Accordingly, mutations in TTBK2 were not found, suggesting a second SCA gene on chromosome 15q as cause of this novel form of SCA. In addition, we excluded alterations in two candidate genes in the linked region, namely expansion of a polyglutamine‐coding CAG repeat in ARID3B and mutations in SEMA6D. © 2010 Movement Disorder Society

Url:

https://api.istex.fr/document/D404B81912783DCC19C384A379AA72D35521AA24/fulltext/pdf

DOI: 10.1002/mds.22857

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15</title>
<author><name sortKey="Weissbach, Anne" sort="Weissbach, Anne" uniqKey="Weissbach A" first="Anne" last="Weissbach">Anne Weissbach</name>
</author>
<author><name sortKey="Djarmati, Ana" sort="Djarmati, Ana" uniqKey="Djarmati A" first="Ana" last="Djarmati">Ana Djarmati</name>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
</author>
<author><name sortKey="Dragasevi, Natasa" sort="Dragasevi, Natasa" uniqKey="Dragasevi N" first="Nataša" last="Dragaševi">Nataša Dragaševi</name>
</author>
<author><name sortKey="Zuhlke, Christine" sort="Zuhlke, Christine" uniqKey="Zuhlke C" first="Christine" last="Zühlke">Christine Zühlke</name>
</author>
<author><name sortKey="Rakovi, Aleksandar" sort="Rakovi, Aleksandar" uniqKey="Rakovi A" first="Aleksandar" last="Rakovi">Aleksandar Rakovi</name>
</author>
<author><name sortKey="Guzvi, Miodrag" sort="Guzvi, Miodrag" uniqKey="Guzvi M" first="Miodrag" last="Gužvi">Miodrag Gužvi</name>
</author>
<author><name sortKey="Butz, Elisabeth" sort="Butz, Elisabeth" uniqKey="Butz E" first="Elisabeth" last="Butz">Elisabeth Butz</name>
</author>
<author><name sortKey="Tonnies, Holger" sort="Tonnies, Holger" uniqKey="Tonnies H" first="Holger" last="Tönnies">Holger Tönnies</name>
</author>
<author><name sortKey="Siebert, Reiner" sort="Siebert, Reiner" uniqKey="Siebert R" first="Reiner" last="Siebert">Reiner Siebert</name>
</author>
<author><name sortKey="Petrovi, Igor" sort="Petrovi, Igor" uniqKey="Petrovi I" first="Igor" last="Petrovi">Igor Petrovi</name>
</author>
<author><name sortKey="Svetel, Marina" sort="Svetel, Marina" uniqKey="Svetel M" first="Marina" last="Svetel">Marina Svetel</name>
</author>
<author><name sortKey="Kosti, Vladimir S" sort="Kosti, Vladimir S" uniqKey="Kosti V" first="Vladimir S." last="Kosti">Vladimir S. Kosti</name>
</author>
<author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D404B81912783DCC19C384A379AA72D35521AA24</idno>
<date when="2010" year="2010">2010</date>
<idno type="doi">10.1002/mds.22857</idno>
<idno type="url">https://api.istex.fr/document/D404B81912783DCC19C384A379AA72D35521AA24/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001D51</idno>
<idno type="wicri:Area/Istex/Curation">001D51</idno>
<idno type="wicri:Area/Istex/Checkpoint">000779</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Weissbach A:possible:genetic:heterogeneity</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:20589871</idno>
<idno type="wicri:Area/PubMed/Corpus">001785</idno>
<idno type="wicri:Area/PubMed/Curation">001785</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001697</idno>
<idno type="wicri:Area/Ncbi/Merge">002C32</idno>
<idno type="wicri:Area/Ncbi/Curation">002C32</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002C32</idno>
<idno type="wicri:Area/Main/Merge">001F36</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:10-0413278</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000960</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002359</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000899</idno>
<idno type="wicri:doubleKey">0885-3185:2010:Weissbach A:possible:genetic:heterogeneity</idno>
<idno type="wicri:Area/Main/Merge">002486</idno>
<idno type="wicri:Area/Main/Curation">001B00</idno>
<idno type="wicri:Area/Main/Exploration">001B00</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15</title>
<author><name sortKey="Weissbach, Anne" sort="Weissbach, Anne" uniqKey="Weissbach A" first="Anne" last="Weissbach">Anne Weissbach</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Luübeck, Luübeck</wicri:regionArea>
<wicri:noRegion>Luübeck</wicri:noRegion>
<wicri:noRegion>Luübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Djarmati, Ana" sort="Djarmati, Ana" uniqKey="Djarmati A" first="Ana" last="Djarmati">Ana Djarmati</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Luübeck, Luübeck</wicri:regionArea>
<wicri:noRegion>Luübeck</wicri:noRegion>
<wicri:noRegion>Luübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Luübeck, Luübeck</wicri:regionArea>
<wicri:noRegion>Luübeck</wicri:noRegion>
<wicri:noRegion>Luübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dragasevi, Natasa" sort="Dragasevi, Natasa" uniqKey="Dragasevi N" first="Nataša" last="Dragaševi">Nataša Dragaševi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Serbie</country>
<wicri:regionArea>Institute of Neurology, Clinical Center of Serbia, Belgrade</wicri:regionArea>
<wicri:noRegion>Belgrade</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zuhlke, Christine" sort="Zuhlke, Christine" uniqKey="Zuhlke C" first="Christine" last="Zühlke">Christine Zühlke</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, University of Luübeck, Luübeck</wicri:regionArea>
<wicri:noRegion>Luübeck</wicri:noRegion>
<wicri:noRegion>Luübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rakovi, Aleksandar" sort="Rakovi, Aleksandar" uniqKey="Rakovi A" first="Aleksandar" last="Rakovi">Aleksandar Rakovi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Luübeck, Luübeck</wicri:regionArea>
<wicri:noRegion>Luübeck</wicri:noRegion>
<wicri:noRegion>Luübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Guzvi, Miodrag" sort="Guzvi, Miodrag" uniqKey="Guzvi M" first="Miodrag" last="Gužvi">Miodrag Gužvi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Luübeck, Luübeck</wicri:regionArea>
<wicri:noRegion>Luübeck</wicri:noRegion>
<wicri:noRegion>Luübeck</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Serbie</country>
<wicri:regionArea>Laboratory for Radiobiology and Molecular Genetics, Institute of Nuclear Sciences “Vinča”, Belgrade</wicri:regionArea>
<wicri:noRegion>Belgrade</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Butz, Elisabeth" sort="Butz, Elisabeth" uniqKey="Butz E" first="Elisabeth" last="Butz">Elisabeth Butz</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Luübeck, Luübeck</wicri:regionArea>
<wicri:noRegion>Luübeck</wicri:noRegion>
<wicri:noRegion>Luübeck</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tonnies, Holger" sort="Tonnies, Holger" uniqKey="Tonnies H" first="Holger" last="Tönnies">Holger Tönnies</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Christian‐Albrechts University, Kiel</wicri:regionArea>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Siebert, Reiner" sort="Siebert, Reiner" uniqKey="Siebert R" first="Reiner" last="Siebert">Reiner Siebert</name>
<affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Human Genetics, Christian‐Albrechts University, Kiel</wicri:regionArea>
<placeName><region type="land" nuts="2">Schleswig-Holstein</region>
<settlement type="city">Kiel</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Petrovi, Igor" sort="Petrovi, Igor" uniqKey="Petrovi I" first="Igor" last="Petrovi">Igor Petrovi</name>
<affiliation wicri:level="1"><country xml:lang="fr">Serbie</country>
<wicri:regionArea>Institute of Neurology, Clinical Center of Serbia, Belgrade</wicri:regionArea>
<wicri:noRegion>Belgrade</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Svetel, Marina" sort="Svetel, Marina" uniqKey="Svetel M" first="Marina" last="Svetel">Marina Svetel</name>
<affiliation wicri:level="1"><country xml:lang="fr">Serbie</country>
<wicri:regionArea>Institute of Neurology, Clinical Center of Serbia, Belgrade</wicri:regionArea>
<wicri:noRegion>Belgrade</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kosti, Vladimir S" sort="Kosti, Vladimir S" uniqKey="Kosti V" first="Vladimir S." last="Kosti">Vladimir S. Kosti</name>
<affiliation wicri:level="1"><country xml:lang="fr">Serbie</country>
<wicri:regionArea>Institute of Neurology, Clinical Center of Serbia, Belgrade</wicri:regionArea>
<wicri:noRegion>Belgrade</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Section of Clinical and Molecular Neurogenetics, Department of Neurology, University of Luübeck, Luübeck</wicri:regionArea>
<wicri:noRegion>Luübeck</wicri:noRegion>
<wicri:noRegion>Luübeck</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2010-08-15">2010-08-15</date>
<biblScope unit="vol">25</biblScope>
<biblScope unit="issue">11</biblScope>
<biblScope unit="page" from="1577">1577</biblScope>
<biblScope unit="page" to="1582">1582</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">D404B81912783DCC19C384A379AA72D35521AA24</idno>
<idno type="DOI">10.1002/mds.22857</idno>
<idno type="ArticleID">MDS22857</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Chromosome 15</term>
<term>Chromosomes, Human, Pair 15 (genetics)</term>
<term>DNA-Binding Proteins (genetics)</term>
<term>Family Health</term>
<term>Female</term>
<term>Genetic Heterogeneity</term>
<term>Genome-Wide Association Study (methods)</term>
<term>Heterogeneity</term>
<term>Humans</term>
<term>Lod Score</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>SCA11</term>
<term>Serbia (epidemiology)</term>
<term>Serbia (ethnology)</term>
<term>Spinocerebellar Ataxias (genetics)</term>
<term>Spinocerebellar ataxia</term>
<term>Trinucleotide Repeats (genetics)</term>
<term>chromosome 15</term>
<term>genetic heterogeneity</term>
<term>genome‐wide linkage analysis</term>
<term>spinocerebellar ataxia</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Serbia</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Serbia</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 15</term>
<term>Spinocerebellar Ataxias</term>
<term>Trinucleotide Repeats</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genome-Wide Association Study</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Family Health</term>
<term>Female</term>
<term>Genetic Heterogeneity</term>
<term>Humans</term>
<term>Lod Score</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Ataxie spinocérébelleuse</term>
<term>Chromosome 15</term>
<term>Hétérogénéité</term>
<term>Pathologie du   système nerveux</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Serbie</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Autosomal dominant spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous group of neurodegenerative disorders. We investigated an SCA family from Serbia of Roma ethnic origin; four affected and nine unaffected family members underwent a detailed neurological examination. The presenting symptom in all patients was gait unsteadiness in early adulthood. Additional features included pyramidal signs, depression, and cognitive impairment. The condition follows an autosomal dominant pattern of inheritance. After excluding repeat expansions in nine known SCA genes, a genome‐wide linkage analysis with 412 microsatellite markers localized the putative disease gene to a 40.7 cM (42.5 Mb) region on chromosome 15q between markers D15S1006 and D15S116. The maximum model‐based multipoint LOD score was 1.75. This region is only 4.3 Mb away from the SCA11 (TTBK2) gene. Accordingly, mutations in TTBK2 were not found, suggesting a second SCA gene on chromosome 15q as cause of this novel form of SCA. In addition, we excluded alterations in two candidate genes in the linked region, namely expansion of a polyglutamine‐coding CAG repeat in ARID3B and mutations in SEMA6D. © 2010 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Serbie</li>
</country>
<region><li>Schleswig-Holstein</li>
</region>
<settlement><li>Kiel</li>
</settlement>
</list>
<tree><country name="Allemagne"><noRegion><name sortKey="Weissbach, Anne" sort="Weissbach, Anne" uniqKey="Weissbach A" first="Anne" last="Weissbach">Anne Weissbach</name>
</noRegion>
<name sortKey="Butz, Elisabeth" sort="Butz, Elisabeth" uniqKey="Butz E" first="Elisabeth" last="Butz">Elisabeth Butz</name>
<name sortKey="Djarmati, Ana" sort="Djarmati, Ana" uniqKey="Djarmati A" first="Ana" last="Djarmati">Ana Djarmati</name>
<name sortKey="Guzvi, Miodrag" sort="Guzvi, Miodrag" uniqKey="Guzvi M" first="Miodrag" last="Gužvi">Miodrag Gužvi</name>
<name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name>
<name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name>
<name sortKey="Rakovi, Aleksandar" sort="Rakovi, Aleksandar" uniqKey="Rakovi A" first="Aleksandar" last="Rakovi">Aleksandar Rakovi</name>
<name sortKey="Siebert, Reiner" sort="Siebert, Reiner" uniqKey="Siebert R" first="Reiner" last="Siebert">Reiner Siebert</name>
<name sortKey="Tonnies, Holger" sort="Tonnies, Holger" uniqKey="Tonnies H" first="Holger" last="Tönnies">Holger Tönnies</name>
<name sortKey="Zuhlke, Christine" sort="Zuhlke, Christine" uniqKey="Zuhlke C" first="Christine" last="Zühlke">Christine Zühlke</name>
</country>
<country name="Serbie"><noRegion><name sortKey="Dragasevi, Natasa" sort="Dragasevi, Natasa" uniqKey="Dragasevi N" first="Nataša" last="Dragaševi">Nataša Dragaševi</name>
</noRegion>
<name sortKey="Guzvi, Miodrag" sort="Guzvi, Miodrag" uniqKey="Guzvi M" first="Miodrag" last="Gužvi">Miodrag Gužvi</name>
<name sortKey="Kosti, Vladimir S" sort="Kosti, Vladimir S" uniqKey="Kosti V" first="Vladimir S." last="Kosti">Vladimir S. Kosti</name>
<name sortKey="Petrovi, Igor" sort="Petrovi, Igor" uniqKey="Petrovi I" first="Igor" last="Petrovi">Igor Petrovi</name>
<name sortKey="Svetel, Marina" sort="Svetel, Marina" uniqKey="Svetel M" first="Marina" last="Svetel">Marina Svetel</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B00 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B00 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:D404B81912783DCC19C384A379AA72D35521AA24
   |texte=   Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15
}}

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15

Possible genetic heterogeneity of spinocerebellar ataxia linked to chromosome 15

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.